Drug Development

Even if we were to make the best use of existing drugs, resistance would arise. With increasing in vitro resistance in many species of bacteria, there is concern that the pace of new antibiotic development has fallen behind the rate of antibiotic obsolescence, although there is evidence that in the case of some drug-resistant infections such as MRSA, there are a number of new drugs in the pipeline.  CDDEP’s work in this area has looked at the rationale for government involvement in incentivizing new drugs and has evaluated potential policy responses. 
 
There are three reasons why private markets may fail in the case of antibiotics.  First, the pharmaceutical industry may be more interested in producing broad spectrum drugs that are more likely to lead to resistance in a wide range of organisms than narrow spectrum drugs that are likely to be more selective in their killing effect.  Second, the market does not incentivize manufacturers to sell drugs in a manner that conserves effectiveness. And third, private markets do not have an incentive to discover new classes of drugs.  The rewards are greater to just produce me-too innovations that are marginal in nature and do not fundamentally replenish our dwindling stock of antibiotic effectiveness. 
 
A number of policies to encourage development of new antibiotics that have been contemplated so far include tax incentives for research spending, patent extensions for other drugs in a pharmaceutical company’s portfolio in exchange for developing a new antibiotic (“wild card” patent extensions), and liability protection from the adverse side effects of new antibiotics. However, the challenge is design a policy that addresses the specific market failures in the context of antibiotics.

Publications

What is antibiotic resistance, and how does it occur? How can we address its threat?

Blog

 Some bacteria are able to avoid antibiotics just by being lazy: the bacteria lack the energy to ingest drugs as they enter a system. Dubbed “persisters,” these bacteria are distinct from...