Malaria

Malaria is both preventable and treatable, yet this mosquito-borne infectious disease takes the life of a child every 30 seconds. It is a major health burden in more than 100 countries and poses a constant threat to economic stability in endemic regions. Fighting malaria faces two challenges: transmission patterns vary from location to location, complicating efforts to target the disease, and resistance to antimalarial drugs is spreading rapidly.
 
CDDEP researchers participate in the Malaria Atlas Project, a spatial database that combines medical intelligence and climate data to track malaria transmission and prevalence. Using a bioeconomic model of malaria transmission and evolution of drug resistance to define optimal treatment strategies, they are developing a strategic plan to tackle the disease. Regional, cross-border coordination will be essential to slow both transmission and the spread of drug-resistant strains. 
 
ACTs, artemisinin-based combination therapies, are effective and can limit the development of further resistance to a valuable antimalarial, but they are expensive. Applying tools from economics, CDDEP researchers helped develop an innovative financing arrangement, the Affordable Medicines Facility–malaria—a global subsidy to make these drugs affordable while addressing the public goods problem of resistance.

Publications

What is the estimated impact, cost, effectiveness and cost-effectiveness of a an artemisinin combination therapy (ACT) subsidy for malaria treatment targeted at children? How could leakage of the...

How does heterogeneous transmission affect the spread of antimalarial drug resistance?

Blog

Rising numbers of drug-resistant pathogens pose a grave concern for the global community. In May, the World Health Organization highlighted the dangers antimicrobial resistance presents on a...

Tools

The high consumption of medically important antibiotics by food animals in the US has been identified as a cause for rising bacterial resistance to antimicrobials. The use of antibiotics for growth promotion in the US became widespread in the 1950s, after it was discovered that adding antibiotics to animal feed accelerated animal growth and cost less than conventional feed supplements. With industrial methods of production becoming more prominent, sub-therapeutic do
The National Institutes of Health (NIH), a part of the US Department of Health and Human Services and the country s medical research agency, is the world s largest funder for medical research. The NIH website states that more than 80% of the agency s budget is used to cover research costs at over 2,500 universities and research institutions.