North America

Consumption of select key retail antibiotics in the United States and India in 2010

Ever since antibiotics were made widely accessible by mass production in the 1940's, their use has increased significantly each decade. However, along with this increase in use, antibiotic effectiveness has also declined. A recent study done by CDDEP showed that global sales of antibiotics for human consumption increased 36% between 2000 and 2011, with Brazil, Russia, India, China, and South Africa accounting for 76% of the increase.

FDA New Molecular Entity Antibiotic Approvals, 1981-2015

This graphic presents an updated and corrected version of an often-plotted chart of FDA antibiotic approvals of the last few decades, and differentiates antibiotics still marketed from antibiotics that were later withdrawn from the market for safety or business reasons. The chart does not purport to reflect the extent to which these agents address unmet medical needs for antibiotics that are active against specific bacteria.  Watch this space for graphics under development that unpack the elements of this issue.

Changes in antibiotic consumption for selected countries, 2000-2010

Column graph shows percent change in antibiotic consumption for selected countries from 2000-2010; BRICS (Brazil, Russia, India, China, South Africa) countries show the highest percentage change. Most countries showing a decrease or maintenance in consumption are high-income countries. Data sourced from Van Boeckel et al, 2014: "Global Antibiotic Consumption 2000 to 2010: An Analysis of National Pharmaceutical Sales Data."

Potential burden of antibiotic resistance on surgery and cancer chemotherapy antibiotic prophylaxis in the USA: a literature review and modelling study

What is the efficacy of antibiotic prophylaxis for surgery and cancer chemotherapy on preventing infections and infection-related deaths in the United States? How would decreased antibiotic efficacy due to antibiotic resistance contribute to additional deaths and infections at different rates of reduced efficacy?


Decline in coronary heart disease mortality in the US, 1980-2000, and the factors contributing to this decline

Mortality due to coronary heart disease has declined significantly in the US during the past few decades. A study published in 2007 in The New England Journal of Medicine by Ford et al. showed that there were 341,745 fewer deaths in 2000 in comparison to 1980.


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