Are oral vancomycin sales are a usefulmarker for Clostridium difficile activity and what historical changes inthe epidemiology of CDI are associated with changes in oral vancomycinprescribing?
What we found
A statistically significant andpositive association between the number of oral vancomycin prescriptions andthe number of CDI cases was determined. Thisindicated that CDI cases are associated with a simultaneous increase in oralvancomycin use.
Why it matters
A change in prescribing oral vancomycincan be viewed as a possible signal for a change in practice and/or possibly achange in the epidemiology of C. difficile.